产品说明
应用
Tumor Necrosis Factor Soluble Receptor I (TNF sRI) from mouse plays a pivotal role in the signaling of apoptosis and NF-κB activation because of its “death domain” present at the intracellular portion.
生化/生理作用
Tumor Necrosis Factor Soluble Receptor I (TNF sRI) from mouse belongs to TNF family of receptors and has a pivotal role in neutralizing the biological activities of both TNF-α and TNF-β. Soluble tumor necrosis factor receptor along with intrathecal interleukin-1 receptor antagonist shows an anti-allodynic action in rat L5 spinal nerve transection model of neuropathic pain.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 2.5 mg bovine serum albumin
分析说明
The biological activity is measured by its ability to inhibit the recombinant mouse TNF-α mediated cytotoxicity in mouse L929 cells, in the presence of the metabolic inhibitor actinomycin D.
基本信息
MDL编号 | MFCD01324859 |
NACRES | NA.32 |
产品性质
质量水平 | 200 |
生物来源 | mouse |
重组 | expressed in E. coli |
测定 | >97% (SDS-PAGE) |
形式 | lyophilized powder |
效能 | 0.5-1.5 μg/mL ED50 |
分子量 | 21 kDa |
包装 | pkg of 50 μg |
储存条件 | avoid repeated freeze/thaw cycles |
technique(s) | cell culture | mammalian: suitable |
杂质 | endotoxin, tested |
UniProt登记号 | P06804 |
储存温度 | −20℃ |
Gene Information | mouse ... Tnfrsf1a(21937) |
安全信息
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich