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Anti-PDGFRB (Ab-751) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4300478
规格纯度
affinity isolated antibody
参考价格
4578.18 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-PDGFRB (Ab-751) antibody produced in rabbit
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Anti-PDGF-R-beta antibody produced in rabbit
Anti-platelet-derived growth factor receptor, beta polypeptide antibody produced in rabbit
Anti-PDGFR antibody produced in rabbit
Anti-CD140B antibody produced in rabbit
产品介绍:

产品说明

一般描述

Platelet derived growth factor receptor β (PDGFRB) is encoded by the gene mapped to human chromosome 5q32. The encoded protein is a type III tyrosine kinase receptor, which exists as a homodimer. This receptor interacts with multiple ligands, but its main physiological ligand is PDGF-BB homodimer.

免疫原

Peptide sequence around aa. 749-753 (V-D-Y-V-P), according to the protein PDGFRB.

生化/生理作用

PDGFRB (platelet derived growth factor receptor β), upon interaction with PGDFB, regulates multiple processes such as, sclerotic disorders, wound healing and tumor angiogenesis. Gain-of-function mutation in this gene is linked with Penttinen syndrome, which is an autosomal-dominant disorder. Release of PGDFB by endothelial cells results in the activation of this receptor, which is essential for the recruitment of PDGFRB+ vascular smooth muscle cells and pericytes during blood vessel formation. Loss-of-function mutation in this gene results in the neurodegenerative disorder primary familial brain calcification (PFBC).

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

PDGF Receptor ? encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD00164777
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 ~190 kDa
species reactivityrat, human
浓度1 mg/mL
technique(s)western blot: 1:500-1:1000
同位素/亚型IgG
免疫原序列(V-D-Y-V-P)
NCBI登记号NP_002600.1
UniProt登记号P09619
运输wet ice
储存温度−20℃
Gene Informationhuman ... PDGFRB(5159)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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