SB 222200

产品名称：

174635-69-9
SB 222200
(S)-3-Methyl-2-phenyl-N-(1-phenylpropyl)-4-quinolinecarboxamide

产品介绍：

产品说明

应用

The pharmacodynamics profile of SB 222200 enables its use as a tool to study physiological and pathophysiological roles of NK-3 receptor in CNS-modulated behaviors.

包装

10, 50 mg in glass bottle

生化/生理作用

SB 222200 is a 2-phenyl-4-quinolinecarboxamides and a selective, reversible and competitive antagonist of human NK-3 receptor that effectively crosses the blood-brain barrier. It inhibits the NK-3 receptor-induced miosis or pupil constriction in conscious rabbits.^1,2
Non-peptide NK₃ tachykinin receptor antagonist.

特点和优势

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律信息

Sold for research purposes under agreement from GlaxoSmithKline

基本信息

经验(实验)分子式	C₂₆H₂₄N₂O
分子量	380.48
MDL编号	MFCD00944072
PubChem化学物质编号	24278254
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
颜色	light yellow
溶解性	DMSO: soluble ~28 mg/mL H₂O: insoluble
创始人	GlaxoSmithKline
储存温度	2-8℃
SMILES string	CC[C@H](NC(=O)c1c(C)c(nc2ccccc12)-c3ccccc3)c4ccccc4
InChI	1S/C26H24N2O/c1-3-22(19-12-6-4-7-13-19)28-26(29)24-18(2)25(20-14-8-5-9-15-20)27-23-17-11-10-16-21(23)24/h4-17,22H,3H2,1-2H3,(H,28,29)/t22-/m0/s1
InChI key	MQNYRKWJSMQECI-QFIPXVFZSA-N
Gene Information	human ... TACR2(6865), TACR3(6870)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)