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Amyloid Precursor Protein β, Secreted human

品牌
Sigma-Aldrich
货号
S4316
规格纯度
recombinant, expressed in E. coli (N-terminal histidine tagged), solution
参考价格
9521.12 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Amyloid Precursor Protein β, Secreted human
Amyloid Precursor Protein β, Secreted
sAPPβ
产品介绍:

产品说明

一般描述

Amyloid-β (Aβ) peptides are a major component of the senile plaques characteristic of the Alzheimer brain. It is a type- I transmembrane protein. The gene encoding amyloid-β is localized on human chromosome 21.

应用

Human amyloid precursor protein β has been used as peptide standard.

包装

25 μg in glass bottle

生化/生理作用

The secreted amyloid precursor β (sAPPβ) is a proteolytic cleavage product of β amyloid precursor protein (APP). APP is cleaved by β-secretase into two fragments, sAPPβ and β-amyloid peptide (Aβ). The Aβ is a component of amyloid plaques, one of the major hallmarks of Alzheimer`s disease (AD), while the sAPPβ is thought to modulate neuronal function and cell survival. Mutation in APP found in Swedish familial AD pedigree increases the susceptibility of APP to β-secretase cleavage and the formation of Aβ and sAPPβ. In contrast, activation of protein kinase C (PKC) decreases the levels of sAPPβ. The trans-Golgi network (TGN) is the major site for β-secretase activity.

外形

0.2 μm filtered solution in 20 mM Tris (pH 7.4), 0.5 M NaCl, 1 mM EDTA, 5 mM βME, 2 μg/ml aprotinin

制备说明

sAPPβ was expressed in E. coli as a soluble protein and purified under non-denaturing conditions

基本信息

MDL编号MFCD06201921
NACRESNA.32

产品性质

质量水平200
重组expressed in E. coli (N-terminal histidine tagged)
形式solution
分子量 ~100 kDa by SDS-PAGE
UniProt登记号P05067
运输dry ice
储存温度−70℃
Gene Informationhuman ... APP(351)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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