产品说明
生化/生理作用
Among the familial mutations of α-synuclein in Parkinson′s disease, E46K has the greatest potential to aggregate. This mutation is a 188G-A transition resulting in a Glu46-to-Lys (E46K) substitution in the amino-terminal region of the protein.
Deposition of α-synuclein as fibrillary tangles is a hallmark of certain neurodegenerative diseases including Parkinson′s. Among the familial mutations of α-synuclein, E46K has the greatest potential to aggregate.
基本信息
NACRES | NA.32 |
产品性质
质量水平 | 200 |
重组 | expressed in E. coli |
测定 | ≥90% (SDS-PAGE) |
形式 | lyophilized powder |
分子量 | apparent mol wt 19-20 kDa |
UniProt登记号 | P37840 |
相容性 | for use with ABI StepOnePlus |
运输 | dry ice |
储存温度 | −20℃ |
Gene Information | human ... SNCA(6622) |
安全信息
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich