产品说明
一般描述
Sphingosine 1-phosphate-induced release of TIMP-2 from vascular smooth muscle cells inhibits angiogenesis.
应用
Sphingosine kinase 1 has been used in a study to assess the modulation of cellular S1P levels. Sphingosine kinase 1 has also been used in a study to investigate how FTY720 normalizes hyperglycemia.
生化/生理作用
Converts sphingosine to sphingosine-1-phosphate. SPHK1 shares two large conserved regions with SPHK2. While SPHK1 is found only in the cytosol, SPHK2 is localized in both the cytosol and nuclei.
单位定义
One unit will produce 1.0 pmole of sphingosine-1-phosphate from ATP and D-erythro-sphingosine per minute at pH 7.4, 37 ℃.
外形
aqueous glycerol solution
Supplied in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween 20, 50% glycerol, 3 mM DTT.
基本信息
| 酶学委员会(EC)编号 | 2.7.1.91 ( BRENDA | IUBMB ) |
| MDL编号 | MFCD09265456 |
| NACRES | NA.54 |
产品性质
| 质量水平 | 200 |
| 重组 | expressed in baculovirus infected insect cells |
| 形式 | solution |
| specific activity | ≥10 units/μg |
| 分子量 | 47 kDa |
| UniProt登记号 | Q9NYA1 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... SPHK1(8877) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
Sigma-Aldrich
m.cnreagent.com
