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Monoclonal Anti-SIAH2 antibody produced in mouse

品牌
Sigma-Aldrich
货号
S7945
规格纯度
clone Siah2-369, purified immunoglobulin, buffered aqueous solution
参考价格
4731.57 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Monoclonal Anti-SIAH2 antibody produced in mouse
Anti-Seven in Absentia Homolog
产品介绍:

产品说明

一般描述

Monoclonal Anti-Siah2 (mouse IgG1 isotype) is derived from the hybridoma Siah2-369 produced by the fusion of mouse myeloma cells (NS1 cell) and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to amino acids 2-17 of human Siah2, conjugated to KLH. Seven in absentia homologue (Siah) is encoded by the gene mapped to human chromosome 3q25.1. Three different Siah genes exist in mice, Siah1a, Siah1b, and Siah2, while humans have only two genes, Siah1and Siah2.

免疫原

synthetic peptide corresponding to amino acids 2-17 of human Siah2, conjugated to KLH.

应用

Monoclonal Anti-Siah2 antibody produced in mouse can be used in enzyme linked immunoassay (ELISA) and immunocytochemistry. It has also been used in immunohistochemistry and immunoblotting.

生化/生理作用

Seven in absentia homologue (Siah) plays a role in the regulation of key proteins in the immune system such as TNF receptor associated factors (TRAF), vav guanine nucleotide exchange factor 1 (Vav1), and oct-binding factor 1 (OBF-1). Siah2 is important for the regulation of the PHD enzymes (prolylhydroxylases) that are responsible for the prolyhydroxylation of HIFα protein under hypoxia conditions.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD08705601
NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆Siah2-369, monoclonal
形式buffered aqueous solution
分子量antigen ~37 kDa
species reactivitymonkey, canine, hamster, mouse, human, bovine
technique(s)immunocytochemistry: suitable
indirect ELISA: suitable
microarray: suitable
western blot: 2-4 μg/mL using total cell extract of HeLa cells
同位素/亚型IgG1
UniProt登记号O43255
运输dry ice
储存温度−20℃
Gene Informationhuman ... SIAH2(6478)
mouse ... Siah2(20439)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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