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位置:首页 > 品牌 > Sigma-Aldrich > Rabbit anti-Phospho RPA32 (S4/S8) Antibody, Affinity Purified

Rabbit anti-Phospho RPA32 (S4/S8) Antibody, Affinity Purified

品牌
Sigma-Aldrich
货号
PLA0071
规格纯度
Powered by Bethyl Laboratories, Inc.
参考价格
6644.93 *本价格含增值税费
促销
服务
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数量
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产品名称:
Rabbit anti-Phospho RPA32 (S4/S8) Antibody, Affinity Purified
RPA32
replication factor A protein 2
RF-A protein 2
replication protein A2
32kDa
replication protein A 34 kDa subunit
RP-A p34
REPA2
RP-A p32
replication protein A2 (32kD)
产品介绍:

产品说明

一般描述

Replication protein A2 (RPA32) is encoded by the gene mapped to human chromosome 1p35.3. It is a subunit of the heterotrimeric replication protein A (RPA) complex.

免疫原

Immunogen was a dually phosphorylated synthetic peptide, which represented a portion of human replication protein A2, 32 kDa surrounding phosphorylated serines that corresponded to positions 4 and 8 using the numbering given in entry NP_002937.1 (GeneID 6118).

生化/生理作用

Replication Protein A (RPA) binds single-stranded DNA and plays a vital role in DNA replication, DNA repair, and checkpoint signaling. Phosphorylation of replication protein A2 (RPA32) by ataxia telangiectasia and Rad3-related protein kinase (ATR) and DNA-dependent protein kinase (DNA-PK) causes checkpoint kinase 1 (Chk1) activation and replication arrest. DNA-PK and ATR signaling via RPA32 (S4/S8) enhances genome stability and cell survival following replication stress.

外形

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

其他说明

Replication protein A (RPA) is a multisubunit complex that carries out DNA mismatch repair (MMR) in association with MSH2 (a subunit of human MutS heterodimers), MLH1 (a subunit of human MutL heterodimers), PCNA, and DNA polymerase-delta. RPA is composed of a heterotrimer that includes subunits of 70 kDa (RPA1), 32kDa (RPA2), and 14kDa (RPA3). RPA2, the 32kDa subunit, is phosphorylated by the cdc2 family of kinases when cells enter S-phase and in response to DNA damage by ATM, ATR, and DNA-PK.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式affinity purified immunoglobulin
antibody product typeprimary antibodies
等级Powered by Bethyl Laboratories, Inc.
species reactivityhuman, mouse
technique(s)immunocytochemistry: 1:500-1:5,000
immunohistochemistry: 1:500-1:2,000
immunoprecipitation (IP): 2-10 μg/mg
western blot: 1:2,000-1:10,000
登记号NP_002937.1
运输wet ice
储存温度2-8℃
Gene Informationhuman ... RPA2(6118)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

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