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TRAIL human

品牌
Sigma-Aldrich
CAS
2244730-93-4
货号
T9701
规格纯度
recombinant, expressed in E. coli, ≥98% (SDS-PAGE and HPLC), lyophilized powder
参考价格
8623.87 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
2244730-93-4
TRAIL human
TL2
Apo2 Ligand
Apo2L
TNF-related apoptosis-inducing ligand
产品介绍:

产品说明

应用

Human TRAIL can be used as a selection agent for treating human cells for phenotypic enrichments. The product can also be used in chemical transfection for identifying Small RNA Modulators of TRAIL-Induced Apoptosis Pathway by utilizing libraries of synthetic small interfering RNA (siRNA) and microRNAs (miRNA).
TRAIL human has been used in immunofluorescence analyses, to study the delocalization of melanoma antigen-D2 in the nucleoplasm after a cellular stress.

生化/生理作用

Type II transmembrane protein of the TNF superfamily. Ligand for apoptosis-inducing death receptors DR4 and DR5, decoy receptors DcR1 and DcR2, and osteoprotegerin. Approximately 28% amino acid sequence identity to FAS ligand. Human and mouse TRAIL share 65% sequence identity.
TRAIL is a cytokine with anti-inflammatory, and antitumor activity. It is expressed in various cells including immune cells, vascular cells and adipocytes. TRAIL is associated with vascular endothelial cell protection.
TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein that belongs to TNF family. The product present in both soluble as well as membrane-bound form, can induce rapid apoptosis of various transformed cell lines but not the normal cells. Additionally, the product can also induce apoptotic cell death in TRAIL-sensitive U343MG cells.

外形

Lyophilized from phosphate buffered saline

分析说明

The biological activity is determined by its ability to induce apoptotic cell death in TRAIL-sensitive LN-18 cells.

基本信息

MDL编号MFCD01867158
NACRESNA.32

产品性质

质量水平200
生物来源human
重组expressed in E. coli
描述extracellular domain
测定≥98% (SDS-PAGE and HPLC)
形式lyophilized powder
分子量 19.6 kDa
predicted mol wt ~21 kDa
technique(s)immunofluorescence: suitable
杂质 endotoxin, tested
UniProt登记号P50591
储存温度−20℃
Gene Informationhuman ... TNFSF10(8743)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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