Terameprocol

产品名称：

24150-24-1
Terameprocol
rel-4-[(2R,3S)-4-(3,4-Dimethoxyphenyl)-2,3-dimethylbutyl]-1,2-dimethoxybenzene
tetra-O-methyl-NDGA
EM-1421
tetramethyl NDGA
M4N
Tetra-O-methyl nordihydroguaiaretic acid
tetramethyl Nordihydroguaiaretic Acid
2,3-Dimethyl-1,4-bis-(3,4-dimethoxyphenyl)butane
TMNDGA

产品介绍：

产品说明

包装

10, 50 mg in glass bottle

生化/生理作用

Terameprocol is a synthetic derivative of NDGA, a non-selective lipoxygenase inhibitor. It inhibits Sp1 transcription factor binding at the HIV long terminal repeat promoter and at the α-ICP4 promoter, a gene essential for HSV replication, with IC50 values of 11 and 43.5 μM respectively. TMNDGA induces growth arrest and apoptosis by suppressing Sp1-dependent Cdc2 and survivin gene expression giving rise to its antitumorigenic activity. The in vivo growth of xenografts in numerous human tumor types was suppressed upon treatment with TMNDGA It also inhibits the growth of murine and human melanomas and human colon cancer in vivo without causing other tissue toxicity.
Terameprocol is known to reduce angiogenesis¹.

制备说明

Terameprocol is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml.

基本信息

经验(实验)分子式	C₂₂H₃₀O₄
分子量	358.47
MDL编号	MFCD11113155
PubChem化学物质编号	329826768
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to off-white
溶解性	DMSO: ≥10 mg/mL
储存温度	−20℃
SMILES string	COc1ccc(C[C@H](C)[C@H](C)Cc2ccc(OC)c(OC)c2)cc1OC
InChI	1S/C22H30O4/c1-15(11-17-7-9-19(23-3)21(13-17)25-5)16(2)12-18-8-10-20(24-4)22(14-18)26-6/h7-10,13-16H,11-12H2,1-6H3/t15-,16+
InChI key	ORQFDHFZSMXRLM-IYBDPMFKSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H410
预防措施声明	P273 - P501
危险分类	Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable