产品说明
应用
Tofisopam has been used for studying its biochemical mechanisms of actions using drug repositioning strategies.
包装
10, 50 mg in glass bottle
生化/生理作用
Studies have reported that tofisopam functions by blocking PDE4 (phosphodiesterase 4). Furthermore, the S-enantiomer of tofisopam is considered ten times more active than R-enantiomer.
Ligand for the GABAA receptor benzodiazepine modulatory site.
制备说明
Tofisopam is soluble in DMSO at approximately 14 mg/ml. However, it is insoluble in water.
基本信息
| 经验(实验)分子式 | C22H26N2O4 |
| 分子量 | 382.45 |
| EC 号 | 244-922-3 |
| MDL编号 | MFCD00823171 |
| PubChem化学物质编号 | 24724636 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| drug control | regulated under CDSA - not available from sigma-aldrich Canada |
| 颜色 | white |
| 溶解性 | DMSO: ~14 mg/mL H2O: insoluble |
| SMILES string | CCC1C(C)=NN=C(c2ccc(OC)c(OC)c2)c3cc(OC)c(OC)cc13 |
| InChI | 1S/C22H26N2O4/c1-7-15-13(2)23-24-22(14-8-9-18(25-3)19(10-14)26-4)17-12-21(28-6)20(27-5)11-16(15)17/h8-12,15H,7H2,1-6H3 |
| InChI key | RUJBDQSFYCKFAA-UHFFFAOYSA-N |
安全信息
| 象形图 |   |
| 警示用语： | Warning |
| 危险声明 | H302 - H400 |
| 预防措施声明 | P273 - P301 + P312 + P330 |
| 危险分类 | Acute Tox. 4 Oral - Aquatic Acute 1 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
Sigma-Aldrich
m.cnreagent.com
