产品说明
应用
TRKA (440-end), active, GST tagged human was used to study functional NGF signal transduction.
生化/生理作用
TRKA (440-end), active, GST tagged human is a 140 kD membrane-spanning protein tyrosine kinase that belongs to proto-oncogene family. TRKA facilitates the regulation of cell differentiation and survival via activating SHC1 and FRS2 which in turn activates a GRB2-Ras-MAPK cascade. It also plays a pivotal role in controlling NF-κ-B activation as well as transcription of genes involved in cell survival via PLCG1.
外形
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
法律信息
PRECISIO is a registered trademark of sigma-aldrich Co. LLC
基本信息
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 生物来源 | human |
| 重组 | expressed in baculovirus infected Sf9 cells |
| 产品线 | PRECISIO® Kinase |
| 测定 | ≥70% (SDS-PAGE) |
| 形式 | buffered aqueous glycerol solution |
| specific activity | 19-25 nmol/min·mg |
| 分子量 | ~66 kDa |
| technique(s) | activity assay: suitable |
| UniProt登记号 | P04629 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... NTRK1(4914) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
Sigma-Aldrich
m.cnreagent.com
