您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 品牌 > Sigma-Aldrich > TrkB/Fc Chimera human

TrkB/Fc Chimera human

品牌
Sigma-Aldrich
货号
T8694
规格纯度
>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
参考价格
11565.1 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
TrkB/Fc Chimera human
产品介绍:

产品说明

应用

TrkB/Fc Chimera human can be used in synaptoneurosome preparation and western blot analysis. Intracerebroventricular administeration of TrkB/Fc chimera human blocks TrkB ligand signaling and was used to study the role of BDNF in ATN response augmentation.

生化/生理作用

Member of the Trk family tyrosine kinase receptors. Binds specifically to mediate neurotrophins BDNF and NT-4/5.
TrkB/Fc Chimera human consist of extracellular domain of human TrkB1 fused to histidine-tagged Fc region of human IgG1 by using a polypeptide linker. TrkB belongs to tyrosine kinase receptors family and facilitates the hippocampal development as well as regulating the synaptic plasticity that underlies long-term potentiation and learning. Brain derived neurotrophic factor (BDNF) and Neurotrophin 4 or 5 are preferred ligands for TrkB. Nevertheless it can also bind to NTF3/neurotrophin-3 that is less efficient in activating the receptor but regulates neuron survival through NTRK2.

其他说明

Extracellular domain of human TrkB fused to the C-terminal histidine-tagged Fc region of human IgG1.

外形

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline.

重悬

Reconstitute to 100 μg/mL in phosphate buffered saline.

分析说明

Inhibits BDNF-induced proliferation of TrkB transfected cells, BaF-TrkB-BD.

基本信息

MDL编号MFCD03458837
NACRESNA.32

产品性质

质量水平200
生物来源human
重组expressed in NSO cells
测定>90% (SDS-PAGE)
形式lyophilized powder
效能0.1-0.4 μg/mL ED50
分子量 120-130 kDa by SDS-PAGE (reducing)
calculated mol wt 71 kDa
包装pkg of 100 μg
储存条件avoid repeated freeze/thaw cycles
technique(s)western blot: suitable
杂质 endotoxin, tested
UniProt登记号Q16620
储存温度−20℃
Gene Informationhuman ... NTRK2(4915)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品