Urocortin human

产品名称：

176591-49-4
Urocortin human

产品介绍：

产品说明

Amino Acid Sequence

Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2

应用

Urocortin human can be used as a test compound for studying the impact of corticotropin-releasing factor (CRF) receptor agonist and antagonist on sleep-wake patterns in conscious rats by using radiotelemetry system.

包装

250 μg in glass bottle

生化/生理作用

Urocortin is a CRF-related neuropeptide having high affinity for CRF2 receptor possess appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein.
Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells.

基本信息

经验(实验)分子式	C₂₀₄H₃₃₇N₆₃O₆₄
分子量	4696.24
MDL编号	MFCD00802621
NACRES	NA.32

产品性质

质量水平	200
生物来源	human
测定	≥85% (HPLC)
形式	powder
technique(s)	ligand binding assay: suitable
UniProt登记号	P55089
储存温度	−20℃
Gene Information	human ... UCN(7349)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)