5-甲酰基-5,6,7,8-四氢蝶酰基-<SC>L</SC>-谷氨酸钙盐

产品名称：

1492-18-8
Calcium folinate for system suitability
Leucovorin calcium salt
5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt
5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt
Folinic acid calcium salt hydrate
Calcium Folinate
5-HCO-H₄PteGlu
Citrovorum factor calcium salt
亚叶酸钙
5-甲酰基-5,6,7,8-四氢蝶酰基-L-谷氨酸钙盐
叶醛酸钙
亚叶酸钙盐水合物
嗜橙菌因子钙盐
甲酰四氢叶酸钙盐
5-甲酰基-5,6,7,8-四氢叶酸钙盐

产品介绍：

产品说明

一般描述

Calcium folinate, the reduced form of folic acid, finds application in the treatment of methotrexate overdose and in high-dose methotrexate chemotherapy as a chemotherapy protective drug to bring down the latter′s toxicity. When combined with fluorouracil, it is reported to be effective in the management of bowel cancer wherein it acts by inhibiting thymidylate synthase and augmenting the effect of fluorouracil.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Calcium folinate for system suitability may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.
叶酸拮抗剂通过结合二氢叶酸还原酶并阻滞叶酸转化为四氢叶酸盐发挥作用，而亚叶酸钙则可抵消叶酸拮抗剂的作用。在医学上，亚叶酸钙在甲氨蝶呤治疗后用于降低甲氨蝶呤的毒性。亚叶酸钙还可用于增强癌症治疗中 5-氟尿嘧啶的细胞毒性效应。

包装

Unit quantity: 10 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₀H₂₁CaN₇O₇ · xH₂O
分子量	511.50 (anhydrous basis)
Beilstein	5723924

产品性质

生物来源	synthetic
等级	pharmaceutical primary standard
agency	EP
形式	solid
manufacturer/tradename	EDQM
technique(s)	gas chromatography (GC): suitable liquid chromatography (LC): suitable
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	−20℃
SMILES string	[Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13

安全信息

象形图
警示用语：	Danger
危险声明	H315 - H317 - H319 - H334 - H335
预防措施声明	P261 - P264 - P280 - P280 - P304 + P340 + P312 - P342 + P311
危险分类	Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官	Respiratory system
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable