Zatebradine hydrochloride

产品名称：

91940-87-3
Zatebradine hydrochloride
7,8-Dimethoxy-3-[3-[-N-[2-(3,4 dimethoxyphenyl)ethyl]-N-methylamino]propyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride
UL-FS49

产品介绍：

产品说明

应用

Zatebradine hydrochloride has been used:

as an I_f blocker to study its effects on cardiomyocyte clusters (CMCs)
as a hyperpolarization-activated and cyclic nucleotide-gated (HCN) channel inhibitor to study its effects on viability of degenerating rod or cone photoreceptors in mice
as a bradycardiac agent to study its effects on tachycardia and elevated temperature in fish

包装

10, 50 mg in glass bottle

生化/生理作用

Zatebradine is a bradycardiac agent.
HCN channel blocker: blocker of neuronal I_h, related cardiac I_f channels and ATP-sensitive K_ir channels.

特点和优势

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式	C₂₆H₃₇ClN₂O₅
分子量	493.04
MDL编号	MFCD06798356
PubChem化学物质编号	24724672
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	white
溶解性	H₂O: >10 mg/mL
创始人	Boehringer Ingelheim
储存温度	2-8℃
SMILES string	Cl[H].COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC
InChI	1S/C26H36N2O5.ClH/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29;/h7-8,15-17H,6,9-14,18H2,1-5H3;1H
InChI key	ZRNKXJHEQKMWCH-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)