R-(+)-DIOA

产品名称：

81166-47-4
R-(+)-DIOA
R(+)-Butylindazone
R-(+)-[(2-n-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid

产品介绍：

产品说明

应用

R-(+)-DIOA has been used as a potassium/chloride K⁺-Cl^- transport inhibitor to study its effects on:

short circuit current (Isc) in rat semicircular canal duct (SCCD) epithelium
uptake of grepafloxacin by THP-1 monocytes
the uptake of moxifloxacin by THP-1 monocytes

包装

10, 50 mg in glass bottle

生化/生理作用

[(dihydroindenyl)oxy]acetic acid (DIOA) acts as a potent inhibitor of potassium/chloride (K⁺–Cl⁻) co-transporter. It does not exert its effects on bumetanimide-sensitive [Na⁺,K⁺,Cl^-]-cotransport system.

基本信息

经验(实验)分子式	C₂₀H₂₄Cl₂O₄
分子量	399.31
MDL编号	MFCD00069261
PubChem化学物质编号	24277830

产品性质

测定	≥98% (HPLC)
形式	solid
旋光性	[α]27/D +18.1°, c = 0.7 in methanol(lit.)
颜色	white
溶解性	H₂O: insoluble <0.11 mg/mL DMSO: >20 mg/mL 0.1 M HCl: insoluble 0.1 M NaOH: soluble ethanol: soluble
SMILES string	CCCC[C@]1(Cc2cc(OCC(O)=O)c(Cl)c(Cl)c2C1=O)C3CCCC3
InChI	1S/C20H24Cl2O4/c1-2-3-8-20(13-6-4-5-7-13)10-12-9-14(26-11-15(23)24)17(21)18(22)16(12)19(20)25/h9,13H,2-8,10-11H2,1H3,(H,23,24)/t20-/m0/s1
InChI key	YAWWQIFONIPBKT-FQEVSTJZSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)