产品说明
一般描述
Interleukin-4 (IL-4) is a pleiotropic cytokine and a potent lymphoid cell growth factor. It is produced by activated T cells and is a ligand for interleukin 4 receptor. The gene encoding this protein is localized on human chromosome 5q31.1. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
生化/生理作用
Interleukin-4 (IL-4) stimulates the growth and survivability of certain B cells and T cells. The interleukin 4 receptor also binds to interleukin-13 (IL-13), which may contribute to many overlapping functions of this cytokine and IL-13. STAT6 (signal transducer and activator of transcription-6) has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This protein exhibits anti-inflammatory responses and has a role in immune processes by protecting against intracellular pathogens.
外形
Lyophilized from a solution of 20 mM Tris-HCl, pH 7.4, with 300 mM NaCl.
制备说明
Centrifuge the vial prior to opening.
重悬
Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
基本信息
| NACRES | NA.32 |
产品性质
| 生物来源 | human |
| 重组 | expressed in HEK 293 cells |
| 测定 | ≥95% (SDS-PAGE) |
| 形式 | lyophilized |
| 分子量 | (14 and 19 kDa, monomer) |
| 包装 | pkg of 10 μg |
| technique(s) | cell culture | mammalian: suitable |
| NCBI登记号 | P05112 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... IL4(3565) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
