Anti-BRCA1 antibody produced in rabbit

产品说明

一般描述

Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene involved in familial breast cancer, mapped to human chromosome 17q21. BRCA1 codes for an 1863-amino acid protein, and is expressed in several human tissues, including breast and ovary. The encoded protein is characterized with an N- terminal C3HC4 zinc finger domain, two nuclear localization sequences (NLS) required for translocation into the nucleus, and a C-terminal end rich in amino acid residues.

免疫原

The antiserum was produced against synthesized peptide derived from human BRCA1.

Immunogen Range: 1391-1440

应用

Anti-BRCA1, C-Terminal antibody produced in rabbit has been used in proximity ligation assay.

生化/生理作用

Breast cancer susceptibility gene 1 (BRCA1) plays a vital role in DNA repair, chromatin remodeling, gene transcription and cell cycle regulation. Detection of BRCA1 gene allows early diagnosis of breast and ovarian cancer susceptibility in some individuals and also facilitates studies related to breast cancer biology. BRCA1 interacts with c-Myc, a proto-oncogene, to maintain genomic stability. Experimental studies reveals that germline mutations in BRCA1 gene causes breast and ovarian cancer. Increased expression of BRCA1 leads to growth retardation and tumor suppression in breast and ovarian cancer cells.

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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