产品说明
一般描述
The C-terminal Src kinase (CSK) gene is mapped to human chromosome 15q24.1. Anti-CSK Antibody detects endogenous levels of total CSK protein.
免疫原
The antiserum was produced against synthesized peptide derived from human CSK.
Immunogen Range: 31-80
生化/生理作用
C-terminal Src kinase (CSK) is known to support dengue virus replication. CSK negatively controls Src, an oncogenic protein found to be upregulated in various types of cancer. CSK is responsible for Src phosphorylation at tyrosine 530, which inhibits its activity. It controls immune response, by preventing T cell activation through its association with lymphoid-specific phosphatase. CSK possesses SH2 domain, a regulatory domain that mediates its binding to scaffold proteins for membrane translocation. This regulation is known to elevate CSK′s activity.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 50 kDa |
| species reactivity | human, mouse, rat |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:5000 immunofluorescence: 1:100-1:500 western blot: 1:500-1:1000 |
| NCBI登记号 | P41240 |
| UniProt登记号 | P41240 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... CSK(1445) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
