产品说明
一般描述
The estrogen receptor 1 (ESR1) gene is mapped to human chromosome 6q25.1-q25.2. The encoded protein belongs to the nuclear hormone receptor family. ESR1 is characterized with a transcription activation function-1 domain (AF-1), a DNA-binding domain (DBD), a hinge domain and a ligand-binding domain (LBD/AF-2).
免疫原
Peptide sequence around aa. 165-169 (L-A-S-T-N), according to the protein ESR1.
生化/生理作用
Estrogen receptor 1 (ESR1) is involved in immune and inflammatory response. Aberrations in ESR1 results in Mayer-Rokitansky-Küster-Hauser syndrome that is associated with the congenital absence of the uterus and the upper two-thirds of the vagina. Polymorphism in the gene increases the risk of susceptibility to fractures. Elevated expression of the gene has been observed in breast cancer patients.
特点和优势
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目标描述
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | ~66 kDa |
| species reactivity | human |
| 浓度 | 1 mg/mL |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 indirect immunofluorescence: 1:100-1:200 western blot: 1:500-1:1000 |
| 同位素/亚型 | IgG |
| 免疫原序列 | (L-A-S-T-N) |
| NCBI登记号 | NP_000116.2 |
| UniProt登记号 | P03372 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... ESR1(2099) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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