产品说明
一般描述
CDK6 (cyclin dependent kinase 6) is a serine/threonine kinase. It is a human PLSTIRE gene product that is located on chromosome 7q21.
免疫原
Peptide sequence around phosphorylation site of tyrosine 24 (G-A-Y(p)-G-K), according to the protein CDK6.
生化/生理作用
CDK6 (cyclin dependent kinase 6) participates in the regulation of cell‐cycle, hence it acts as a target for cancer therapy. Upregulation of CDK6 has been observed in various malignancies like leukemia and lymphomas. In hematopoietic stem cells, CDK6 modulates the exit of quiescence.
特点和优势
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目标描述
Probably involved in the control of the cell cycle. Interacts with D-type G1 cyclins.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | ~36 kDa |
| species reactivity | rat, mouse, human |
| 浓度 | 1 mg/mL |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 indirect immunofluorescence: 1:100-1:200 western blot: 1:500-1:1000 |
| 同位素/亚型 | IgG |
| 免疫原序列 | (G-A-YP-G-K) |
| NCBI登记号 | NP_001138778.1 |
| UniProt登记号 | Q00534 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... CDK6(1021) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
