Anti-phospho-IR (pTyr¹³⁵⁵) antibody produced in rabbit

产品说明

一般描述

Insulin receptor (INSR) is located on human chromosome 19. It has 22 exons spanning 120 kilobases. The gene product of INSR has a leader sequence of 27 amino acids.

免疫原

The antiserum was produced against synthesized peptide derived from human IR around the phosphorylation site of Tyr1355.

Immunogen Range: 1326-1375

生化/生理作用

Insulin binds to its receptor (INSR) or to the structurally related insulin-like growth factor-I receptor (IGFIR) to control the development and apoptosis of cells. Aberrations in exon 17 of insulin receptor (INSR) gene result in PCOS (polycystic ovary syndrome). It plays a key role in insulin metabolism. Mutations in INSR results in insulin-resistant syndromes like leprechaunism (donohue syndrome), rabson–mendenhall syndrome and type A insulin resistance.

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品性质

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