产品说明
免疫原
The antiserum was produced against synthesized peptide derived from human MEK1/2 around the phosphorylation site of Ser221.
Immunogen Range: 193-242
生化/生理作用
MAP2k1/2 (dual specificity mitogen-activated protein kinase kinase 1/2) is a serine threonine kinase and is required for ERK (extracellular-signal-regulated kinase) activation. Activation of ERK is associated with production of IL-10 (interleukin 10) and IL-12. Absence of the Map2k1 gene results in embryonic lethality. Map2k1 is responsible for the stimulation of epidermal proliferation, regulating cell migration in fibroblasts. Deficiency of Map2k1 protein causes lupus-like syndrome. The gene encoding Map2k1 is localized on human chromosome 15q22.31 and the MAP2K2 gene is localized on human chromosome 19p13.3.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 43 kDa |
| species reactivity | human, rat, mouse |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:20000 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000 |
| NCBI登记号 | P36507 Q02750 |
| UniProt登记号 | P36507 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... MAP2K1(5604), MAP2K2(5605) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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