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Anti-phospho-MET (pTyr1234) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4300182
规格纯度
affinity isolated antibody
参考价格
4618.16 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-phospho-MET (pTyr1234) antibody produced in rabbit
Anti-c-Met antibody produced in rabbit
Anti-HGFR antibody produced in rabbit
Anti-RCCP2 antibody produced in rabbit
Anti-met proto-oncogene (hepatocyte growth factor receptor) antibody produced in rabbit
Anti-AUTS9 antibody produced in rabbit
产品介绍:

产品说明

一般描述

Mesenchymal epithelial transition (MET) is a proto oncogene, mapped to human chromosome 7q21–q31. The encode protein is a transmembrane receptor tyrosine kinase (RTK) and is activated by an endogenous ligand, scatter factor or hepatocyte growth factor (HGF) .

免疫原

Peptide sequence around phosphorylation site of tyrosine 1234 (K-E-Y(p)-Y-S), according to the protein MET.

生化/生理作用

Mesenchymal epithelial transition (MET) facilitates wound healing and hepatic regeneration, with vital roles in embryonic, neuronal and muscle development.Mutations in the gene leads to non-small cell lung cancer (NSCLC). Copy number (GCN) of c-MET acts as a potential marker to determine poor prognosis in ovarian carcinoma patients. Binding of hepatocyte growth factor (HGF) to MET activates downstream signaling of various pathway, including mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K)/AKT (protein kinase B), signal transducer and activator of transcription proteins, and nuclear factor-κB.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD01633070
NACRESNA.41

产品性质

生物来源rabbit
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 ~156 kDa
species reactivityrat, human, mouse
浓度1 mg/mL
technique(s)western blot: 1:500-1:1000
同位素/亚型IgG
免疫原序列(K-E-YP-Y-S)
NCBI登记号NP_000236.2
UniProt登记号P08581
运输wet ice
储存温度−20℃
Gene Informationhuman ... MET(4233)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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