产品说明
一般描述
Mesenchymal epithelial transition (MET) is a proto oncogene, mapped to human chromosome 7q21–q31. The encode protein is a transmembrane receptor tyrosine kinase (RTK) and is activated by an endogenous ligand, scatter factor or hepatocyte growth factor (HGF) .
免疫原
Peptide sequence around phosphorylation site of tyrosine 1234 (K-E-Y(p)-Y-S), according to the protein MET.
生化/生理作用
Mesenchymal epithelial transition (MET) facilitates wound healing and hepatic regeneration, with vital roles in embryonic, neuronal and muscle development.Mutations in the gene leads to non-small cell lung cancer (NSCLC). Copy number (GCN) of c-MET acts as a potential marker to determine poor prognosis in ovarian carcinoma patients. Binding of hepatocyte growth factor (HGF) to MET activates downstream signaling of various pathway, including mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K)/AKT (protein kinase B), signal transducer and activator of transcription proteins, and nuclear factor-κB.
特点和优势
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目标描述
Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD01633070 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | ~156 kDa |
| species reactivity | rat, human, mouse |
| 浓度 | 1 mg/mL |
| technique(s) | western blot: 1:500-1:1000 |
| 同位素/亚型 | IgG |
| 免疫原序列 | (K-E-YP-Y-S) |
| NCBI登记号 | NP_000236.2 |
| UniProt登记号 | P08581 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... MET(4233) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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