产品说明
一般描述
MKP1 (mitogen-activated protein kinase phosphatase 1)/DUSP1 (dual specificity phosphatase 1) is a dual specificity phosphatase. DUSP1 is also called as CL100, 3CH134 and Erp. MKP1 is located in the nucleus and is expressed in several tissues. The MKP gene is located on human chromosome 5q35.
免疫原
The antiserum was produced against synthesized peptide derived from human MKP-1/2 around the phosphorylation site of Ser296/318.
Immunogen Range: 261-310
生化/生理作用
In mast cells, MKP1 (mitogen-activated protein kinase phosphatase 1) blocks the functions of extracellular signal-regulated kinase (Erk)‐1/2 by glucocorticoid. It controls axon branching promoted by BDNF (brain-derived neurotrophic factor). These results suggest that that DUSP4 is a critical regulator of the growth and invasion of triple-negative breast cancer cells. DUSP4 specifically regulates extracellular regulated kinase (ERK). DUSP4 is an important tumor suppressor gene in these aggressive breast cancers.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 39 kDa |
| species reactivity | mouse, rat, human |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:5000 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000 |
| NCBI登记号 | P28562 Q13115 |
| UniProt登记号 | P28562 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... DUSP1(1843), DUSP4(1846) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
