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Anti-phospho-PKC α (pTyr657) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4301254
规格纯度
affinity isolated antibody
参考价格
6141.35 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-phospho-PKC α (pTyr657) antibody produced in rabbit
PKC III
KPCA
PKC-alpha
PKC-A
产品介绍:

产品说明

一般描述

Protein kinase C α (PRKCA) is encoded by the gene mapped to human chromosome 17q24.2. The encoded protein is a member of the serine/threonine-specific protein kinase family.

特异性

The antibody detects endogenous levels of PKC α only when phosphorylated at tyrosine 658.

免疫原

Peptide sequence around phosphorylation site of tyrosine 658(F-S-Y(p)-V-N) derived from Human PKC α.

生化/生理作用

Protein kinase C α (PRKCA) is a serine-threonine kinase. It is associated with tumorigenesis, invasion, apoptosis, differentiation, angiogenesis and metastasis. Downregulation of PKCA inhibits the invasion of urinary bladder, colon, renal cell, breast carcinomas, multiple myeloma, glioma and endometrial cancer cells. In endothelial cells, PRKCA-mediated phosphorylation of TRPC1 (transient receptor potential cation channel subfamily C member 1) regulates store operated Ca2+ entry.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 80 kDa
species reactivityhuman
浓度1.0 mg/mL
technique(s)western blot: 1:500-1:1000 (Cell Lysate)
同位素/亚型IgG
登记号NP_002728.1.
UniProt登记号P17252
运输wet ice
储存温度−20℃
Gene Informationhuman ... PRKCA(5578)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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