产品说明
一般描述
Spleen associated tyrosine kinase (SYK) belongs to an autonomous family of cytosolic non-receptor tyrosine kinases. SYK have a tandem of Src Homology 2 (SH2) domain, a C-terminal kinase domain and lacks SH3 domain. SYK is expressed in neurons, hepatocytes, nasal fibroblast, vascular endothelial cells, hematopoietic cells and mammary epithelial cells. In human chromosome, the gene SYK is localized on 9q22.
特异性
The antibody detects endogenous levels of SYK only when phosphorylated at tyrosine 352.
免疫原
Peptide sequence around phosphorylation site of tyrosine 352(S-P-Y(p)-A-D) derived from Human SYK.
应用
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
生化/生理作用
Spleen associated tyrosine kinase (SYK) is a key component of B cell receptor (BCR) signalling pathway and the disruption of SYK leads to blocking of BCR downstream cell signalling. SYK is also involved in the downstream signalling of T cell receptor (TCR). SYK expression level is high in thymocytes than in mature T cells. SYK is critically required for high-affinity IgE receptor (FcεRI) mediated calcium mobilization, degranulation, cytokine production and metabolism of arachidonic acid. In platelets, SYK through interaction with Fc gamma receptor (FcRγ) is essential for collagen receptor mediated signalling pathway. SYK protects B cells from oxidative stress mediated apoptosis by modulating caspase 9 and activation of serine/threonine-specific protein kinase (Akt) survival pathway. SYK plays a key role in maintaining vascular integrity in vivo. SYK is a tumor suppressor gene in breast cancer. SYK is a prognostic marker for chemonaive lymph node negative colon cancer.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 72 kDa |
| species reactivity | human |
| 浓度 | 1.0 mg/mL |
| technique(s) | western blot: 1:500-1:1000 (Cell Lysate) |
| 同位素/亚型 | IgG |
| 登记号 | NP_001167638.1. |
| UniProt登记号 | P43405 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... SYK(6850) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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