产品说明
一般描述
RNA polymerase II subunit A (POLR2A) gene with 29 exons is mapped on human chromosome 17p13.1. This gene codes for a catalytic subunit of RNA polymerase II. The encoded protein consists of a highly conserved 5′ flanking region.
免疫原
peptide corresponding to the N-terminal region of human POLR2A, conjugated to KLH. The corresponding sequence is identical in mouse, rat, monkey, bovine, dog and pig.
生化/生理作用
RNA polymerase II subunit A (POLR2A) catalyzes the synthesis of messenger RNA in eukaryotes. The 5′ flanking domain of RNA polymerase II subunit A (POLR2A) plays a vital role in transcriptional regulation. Mutation in the gene is associated with the pathogenesis of meningiomas.
外形
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | Ig fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~250 kDa |
| species reactivity | human |
| technique(s) | immunoprecipitation (IP): 5-10 μL using whole extract of human HeLa cells indirect immunofluorescence: 1:400-1:800 using human HeLa cells western blot: 1:2000-1:4000 using nuclear extracts of HeLa cells |
| UniProt登记号 | P24928 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... POLR2A(5430) mouse ... Polr2a(20020) rat ... Polr2a(363633) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
