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Anti-Progesterone Receptor antibody, Rabbit monoclonal

品牌
Sigma-Aldrich
货号
SAB5500165
规格纯度
clone SP2, recombinant, expressed in proprietary host, tissue culture supernatant
参考价格
6141.35 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Progesterone Receptor antibody, Rabbit monoclonal
产品介绍:

产品说明

一般描述

The progesterone receptor (PgR) is an estrogen-regulated protein. It has been proposed that expression of PgR determination indicates a responsive estrogen receptor (ER) pathway. A number of studies have shown that PgR determination provides supplementary information to ER.
Progesterone receptor (PGR) belongs to the steroid/thyroid hormone receptor family of ligand-activated transcription factors. It possesses the amino-terminal AF1 region, the central DNA-binding domain (DBD) and the carboxyl-terminal ligand- binding domain (LBD). The PGR gene is localized on human chromosome 11q22.1.

免疫原

Recombinant protein encoding aa 412-526 of human progesterone receptor.

生化/生理作用

Progesterone receptor (PGR) functions as a transcription factor,
which modulates the transcription of target genes in response to progesterone and other hormones. It is phosphorylated on multiple sites and at times, the phosphorylation changes according to the hormone involved. During hormone unavailability, PGR is bound to heat shock proteins. When the ligand binds, it causes the release of PGR from heat shock proteins. It is then translocated to the nucleus, where it binds to its DNA response elements (SREs) and to the components of the transcription machinery. PGR also binds to chromatin templates and results in chromatin remodeling adjacent to the PGR-binding sites.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

0.1 ml rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
重组expressed in proprietary host
偶联物unconjugated
抗体形式tissue culture supernatant
antibody product typeprimary antibodies
克隆SP2, monoclonal
species reactivityhuman (tested)
species reactivity (predicted by homology)pig, rabbit, bovine
technique(s)immunohistochemistry: 1:400
同位素/亚型IgG
UniProt登记号P06401
运输wet ice
储存温度2-8℃
Gene Informationhuman ... PGR(5241)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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