产品说明
一般描述
IL-16 (interleukin 16), or LCF (lymphocyte chemoattractant factor), was first functionally and biochemically characterized in 1982. IL-16 is produced as a precursor protein (pro-IL16), composed of 631 residues which undergoes cleavage by caspase-3 to produce and secrete a C-terminal biologically active peptide of 121 amino acids. This gene is localized to human chromosome 15q26.3.
生化/生理作用
IL-16 (interleukin 16) is a pleiotropic proinflammatory cytokine that stimulates chemotactic and immunomodulatory responses of CD4+ (cluster of differentiation) lymphocytes, monocytes, and eosinophils, via signaling through CD4. It prevents HIV (human immunodeficiency virus) replication, and promotes the expression of IL-2R by human T-cells. Study in Chinese population show that polymorphisms in this gene are linked with susceptibility to knee osteoarthritis (OA). IL-16 plays a key role in the release of tumor-related inflammatory cytokines, and the rs4778889 variant in this gene is linked with increased risk of RCC (renal cell cancer) in Chinese population.
Human and murine IL-16 show significant cross-species reactivity. Recombinant human IL-16 is a 12.4kDa protein consisting of 121 amino acid residues.
序列
SAASASAASD VSVESTAEAT VCTVTLEKMS AGLGFSLEGG KGSLHGDKPL TINRIFKGAA SEQSETVQPG DEILQLGGTA MQGLTRFEAW NIIKALPDGP VTIVIRRKSL QSKETTAAGD S
外形
Lyophilized from 5 mM Sodium Citrate, pH 5.5 + 0.5 mM DTT.
重悬
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a stabilizer (example 5% Trehalose) and store in working aliquots at -20℃ to -80℃.
基本信息
NACRES | NA.32 |
产品性质
生物来源 | human |
重组 | expressed in E. coli |
测定 | ≥98% (HPLC) ≥98% (SDS-PAGE) |
形式 | lyophilized |
分子量 | 12.4 kDa |
包装 | pkg of 10 μg |
technique(s) | cell culture | mammalian: suitable |
杂质 | <0.1 EU/μg endotoxin, tested |
颜色 | white to off-white |
UniProt登记号 | Q14005 |
运输 | wet ice |
储存温度 | −20℃ |
Gene Information | human ... IL16(3603) |
安全信息
象形图 | |
警示用语: | Warning |
危险声明 | H319 |
预防措施声明 | P264 - P280 - P305 + P351 + P338 - P337 + P313 |
危险分类 | Eye Irrit. 2 |
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich