产品说明
一般描述
IL-24 is produced by a variety of cell types, including B cells, CD4+ cells, NK cells, lymph node DCs, monocytes, and melanoma cells. IL-24 can signal through the IL20R1/IL20R2 and IL22R1/IL20R2 receptors to initiate a signaling cascade which includes the induction of JAK1/STAT3 phosphorylation. IL-24 is, functionally, a pleiotropic protein but is generally characterized as an anti-cancer cytokine that can selectively inhibit growth of a wide variety of human cancer cells through activities that include the induction of differentiation and apoptosis, and the suppression of angiogenesis and cell proliferation.
生化/生理作用
IL-24 is a secreted glycoprotein belonging to the IL-10 structural family of cytokines. Recombinant human IL-24 is an 18.9 kDa glycoprotein, containing 161 amino acid residues, including a C-terminal His-tag.
外形
Lyophilized from 10 mM Sodium Phosphate, pH 7.5.
重悬
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.
基本信息
| NACRES | NA.32 |
产品性质
| 生物来源 | human |
| 重组 | expressed in CHO cells |
| 测定 | ≥95% (HPLC) ≥95% (SDS-PAGE) |
| 形式 | lyophilized |
| 分子量 | 18.9 kDa |
| 包装 | pkg of 20 μg |
| 杂质 | <0.1 EU/μg endotoxin, tested |
| 颜色 | white to off-white |
| UniProt登记号 | Q13007 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... IL24(11009) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
