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MIF human

品牌
Sigma-Aldrich
货号
SRP3321
规格纯度
recombinant, expressed in insect cells, ≥98% (SDS-PAGE), ≥98% (HPLC)
参考价格
4299.51 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
MIF human
MMIF
GIF
GLIF
产品介绍:

产品说明

一般描述

Macrophage migration inhibitory factor (MIF) is a small secreted protein that can act as a pleiotropic pro-inflammatory cytokine as well as an enzyme. MIF pro-inflammatory activity can be initiated by signaling through cluster of differentiation 74 and 44 (CD74 and CD44), resulting in the secretion of tumor necrosis-α (TNF-α), interleukins-1, -6, -8, and various matrix metalloproteinases (MMPs). The gene encoding this protein is localized on human chromosome 22q11.23. Insect cell derived recombinant MIF is a 15kDa protein containing 124 amino acid residues, including an N-terminal His-tag.

生化/生理作用

The enzymatic activity of macrophage migration inhibitory factor (MIF) is characterized by its ability to act as a tautomerase, capable of catalyzing the keto to enol isomerization of keto-phenylpyruvate and L-dopachrome. It appears as though MIF catalytic activity is dependent upon a trimeric configuration and a free N-terminal proline residue.

外形

Lyophilized from 10mM Sodium Phosphate, pH 7.0.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in insect cells
测定≥98% (HPLC)
≥98% (SDS-PAGE)
形式lyophilized
分子量 15.0 kDa
包装pkg of 25 μg
杂质 endotoxin, tested
UniProt登记号P14174
运输wet ice
储存温度−20℃
Gene Informationhuman ... MIF(4282)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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