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Persephin from mouse

品牌
Sigma-Aldrich
货号
SRP3230
规格纯度
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
参考价格
4743.58 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
Persephin from mouse
PSP
PSPN
产品介绍:

产品说明

一般描述

Persephin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF (glial cell line-derived neurotrophic factor), Artemin, and Neurturin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFRα (α1-α4) receptors. The GFRα4 was first identified in chicken and was later shown to be the preferential binding subunit for Persephin. Persephin promotes the survival of ventral midbrain dopaminergic neurons and motor neurons after sciatic nerve axotomy, and like GNDF, promotes ureteric bud branching. Recombinant murine Persephin is a disulfide-linked homodimer, composed of two 10.3 kDa polypeptide chains (96 total amino acid residues). Each chain contains seven conserved cysteine residues, one of which (Cys 63) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration. Persephin is one of the GDNF family ligands and belongs to transforming growth factor β (TGF-β) superfamily.

生化/生理作用

In contrast to GDNF (glial cell line-derived neurotrophic factor) and neurturin, persephin does not support survival of peripheral neurons. Persephin induces differentiation of mesencephalic dopaminergic neurons.

序列

ALAGSCRLWS LTLPVAELGL GYASEEKVIF RYCAGSCPQE ARTQHSLVLA RLRGRGRAHG RPCCQPTSYA DVTFLDDQHH WQQLPQLSAA ACGCGG

外形

Lyophilized from 10 mM Sodium Citrate, pH 4.0.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer and store in working aliquots at -20℃ to -80℃.

基本信息

NACRESNA.32

产品性质

生物来源mouse
重组expressed in E. coli
测定≥98% (HPLC)
≥98% (SDS-PAGE)
形式lyophilized
效能≤0.1 ng/mL ED50
分子量 10.3 kDa
包装pkg of 20 μg
technique(s)cell culture | mammalian: suitable
杂质<0.1 EU/μg endotoxin, tested
颜色 white to off-white
UniProt登记号O70300
运输wet ice
储存温度−20℃
Gene Informationmouse ... PSPN(19197)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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