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sRANK Ligand from rat

品牌
Sigma-Aldrich
货号
SRP6231
规格纯度
recombinant, expressed in E. coli, ≥98% (SDS-PAGE)
参考价格
4532.66 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
sRANK Ligand from rat
TRANCE Receptor
ODAR (osteoclast differentiation and activation receptor)
ODFR (osteoclast differentiation factor receptor)
TNFRSF11A
产品介绍:

产品说明

一般描述

RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T cell proliferation and to promote the survival of RANK + T cells. RANK is also expressed in a variety of tissues including skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. The RANK/RANKL interaction is important in the regulation of osteoclastogenesis and in dendritic-cell-mediated T cell immune responses. Impairments in RANK signaling have been implicated in the induction of expansive osteolysis and Paget disease of bone (PDB2). Recombinant human sRANK receptor is a 19.3 kDa polypeptide containing the TNFR homologous cysteine rich portion of the extracellular domain of RANK receptor (175 amino acid residues).

外形

Sterile filtered through a 0.2 micron filter. Lyophilized from 5 mM Sodium Phosphate, pH 7.6 and 75 mM NaCl.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRESNA.32

产品性质

生物来源rat
重组expressed in E. coli
测定≥98% (SDS-PAGE)
形式lyophilized powder
分子量 19.4 kDa
包装pkg of 10 μg
pkg of 50 μg
杂质<1 EU/μg endotoxin (LAL test)
UniProt登记号O00300
运输wet ice
储存温度−20℃
Gene Informationhuman ... TNFRSF11(4982)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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