Afatinib dimaleate

产品名称：

850140-73-7
Afatinib dimaleate
BIBW 2992 dimaleate
(S,E)-N-(4-(3-Chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide dimaleate
(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]--7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide, (2Z)-2-butenedioate (1:2)
BIBW-2992 dimaleate
BIBW2992 dimaleate

产品介绍：

产品说明

生化/生理作用

Afatinib (BIBW2992) is an orally active, irreversible, potent and selective EGFR/HER2 (ErbB2) dual inhibitor (EGFR IC50 = 0.5 nM (Wt), 0.4 nM (L858R), 10 nM (L858R/T790M); HER2 IC50 = 14 nM) that covalently targets EGFR Cys773 and HER2 Cys805 residues. BIBW2992 suppresses 100 ng/mL EGF-induced EGFR/HER2 tyrosin phosphorylation (IC50 = 13-71 nM; A431, NIH-3T3-HER2, BT-474, NCI-N87), inhibits cancer cells survival in cultures and induces tumor regression in xenograft and transgenic lung cancer models in vivo (20 mg/kg/day p.o.).

基本信息

经验(实验)分子式	C₃₂H₃₃ClFN₅O₁₁
分子量	718.08
MDL编号	MFCD25974239

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	H₂O: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	OC(/C=C\C(O)=O)=O.OC(/C=C\C(O)=O)=O.CN(C)C/C=C/C(NC1=CC(C(NC2=CC=C(F)C(Cl)=C2)=NC=N3)=C3C=C1O[C@H]4CCOC4)=O

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H319 - H373
预防措施声明	P260 - P264 - P270 - P301 + P312 - P305 + P351 + P338 - P314
危险分类	Acute Tox. 4 Oral - Eye Irrit. 2 - STOT RE 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable