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Agrin Human

品牌
Sigma-Aldrich
货号
SAE0095
规格纯度
Recombinant, cell culture tested, expressed in HEK 293 cells
参考价格
4268.36 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Agrin Human
AGRN
Proteoglycan
产品介绍:

产品说明

一般描述

Agrin C-terminal human recombinant is expressed in human HEK 293 cells as a glycoprotein with a calculated molecular mass of 87 kDa (amino acids Ala1260-Pro2045, with an N-terminal His tag). The DTT-reduced protein migrates as a ∼100 kDa polypeptide on SDS-PAGE due to glycosylation. This protein is manufactured in human cells, with no serum. The human cells expression system allows human-like glycosylation and folding, and often supports higher bioactivity of the protein.

生化/生理作用

Agrin is a large extracellular heparan sulfate proteoglycan that is involved in the formation of the neuromuscular junction.
Agrin triggers the aggregation of acetylcholine receptors via the muscle-specific kinase (MuSK) and the low-density lipoprotein receptor-related protein 4 (Lrp4) receptor complex.
Agrin is required for the full regenerative capacity of neonatal mouse hearts.
Recombinant agrin has been shown in vitro to promote cardiomyocyte proliferation, as studied in mouse-induced and human-induced pluripotent stem cells. Recombinant agrin has been shown in vivo to promote cardiac regeneration, after induction of myocardial infarction in adult mice.

产品性质

重组expressed in HEK 293 cells
测定≥95% (SDS-PAGE)
形式lyophilized powder
效能 attachment assay, measured by the ability of the immobilized agrin to support the adhesion of PC12 cells
technique(s)cell culture | mammalian: suitable
适用性endotoxin tested
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 2

Sigma-Aldrich

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