爱维莫潘

产品名称：

156053-89-3
Alvimopan
LY-246736
N-[(2S)-2-[[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]glycine
ADL-8-2698
爱维莫潘

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Alvimopan is a gastroprokinetic peripheral mu-opioid receptor antagonist. As a drug, Alvimopan is given to patients undergoing bowel surgery to protect the bowel from the effects of opioid medications that are used to treat pain, blocking the undesirable GI side-effects of the opioid agonists without affecting analgesia or causing withdrawal. Alvimopan does not cross the blood-brain barrier, competitively binding to gastrointestinal tract mu-opioid receptors.

基本信息

经验(实验)分子式	C₂₅H₃₂N₂O₄
分子量	424.53
MDL编号	MFCD09838268
PubChem化学物质编号	329825803
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D +46 to +52°, c = 1.0 in DMSO
颜色	white to beige
溶解性	DMSO: 10 mg/mL, clear
储存温度	2-8℃
SMILES string	C[C@H]1CN(C[C@@H](C(NCC(O)=O)=O)CC2=CC=CC=C2)CC[C@]1(C3=CC=CC(O)=C3)C
InChI	1S/C25H32N2O4/c1-18-16-27(12-11-25(18,2)21-9-6-10-22(28)14-21)17-20(24(31)26-15-23(29)30)13-19-7-4-3-5-8-19/h3-10,14,18,20,28H,11-13,15-17H2,1-2H3,(H,26,31)(H,29,30)/t18-,20-,25+/m0/s1
InChI key	UPNUIXSCZBYVBB-JVFUWBCBSA-N
Gene Information	human ... OPRM1(4988)

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H400
预防措施声明	P273 - P302 + P352 - P305 + P351 + P338
危险分类	Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable