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Androgen receptor (650-920), human

品牌
Sigma-Aldrich
货号
SRP2071
规格纯度
recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
参考价格
6666.1 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Androgen receptor (650-920), human
AIS
TFM
KD
HUMARA
NR3C4
DHTR
HYSP1
SBMA
SMAX1
产品介绍:

产品说明

生化/生理作用

The androgen receptor is an androgen-activated member of the nuclear receptor superfamily of transcription factors. Signaling by the androgen receptor plays a key role in proper development and function of male reproductive organs. The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. The androgen receptor (AR) has been shown to play a critical role in the development and progression of prostate cancer.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRESNA.26

产品性质

生物来源human
重组expressed in E. coli
测定≥70% (SDS-PAGE)
形式frozen liquid
分子量 ~33.7 kDa
包装pkg of 10 μg
储存条件avoid repeated freeze/thaw cycles
浓度300  μg/mL
颜色 clear
colorless
NCBI登记号NM_000044
UniProt登记号P10275
运输dry ice
储存温度−70℃
Gene Informationhuman ... AR(367)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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