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Anti-IDH1 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200592
规格纯度
~1.0 mg/mL, affinity isolated antibody
参考价格
5045.46 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-IDH1 antibody produced in rabbit
Anti-IDH
Anti-IDP
Anti-PICD
Anti-soluble
Anti-isocitrate dehydrogenase 1 (NADP+)
产品介绍:

产品说明

一般描述

Isocitrate dehydrogenase 1 (IDH1) is an isoform of IDH enzyme. It is a cytoplasmic NADP+-dependent enzyme, localized both in the cytoplasm and peroxisomes.

免疫原

synthetic peptide corresponding to an internal sequence of human IDH1, conjugated to KLH. The corresponding sequence is highly conserved in mouse (single amino acid substitution) and highly conserved in rat IDH1 (89% sequence identity).

生化/生理作用

Isocitrate dehydrogenase (IDH) is a key metabolic enzyme that catalyzes the oxidative decarboxylation of isocitrate into α-ketoglutarate (αKG) in the cytosol, by using either NAD+ or NADP+ as co-substrates. IDH1 appears to have a tumor suppressor activity and its inactivation leads to tumorigenesis partially mediated by induction of the HIF1 pathway. A genome-wide mutation study has shown that IDH1 is mutated in glioblastoma, acute myeloid leukemia (AML) and chondrosarcoma. Mutations in IDH1 specific to Arg132 (R132) impart the enzyme′s ability to generate 2- hydroxyglutarate (2HG) instead of αKG. Several IDH1 mutations have been identified in gliomas, including R132H, R132C, R132S, R132G and R132L, each may result in different tumor type with varied malignant progression.

外形

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
species reactivitymouse, human
浓度~1.0 mg/mL
technique(s)immunoblotting: 1-2 μg/mL using extracts of mouse brain (S1 fraction).
immunoprecipitation (IP): 10 μg using lysates of HepG2 cells.
indirect immunofluorescence: 2-4 μg/mL using U-87 glioblastoma cells.
UniProt登记号O75874
运输dry ice
储存温度−20℃
Gene Informationhuman ... IDH1(3417)

安全信息

储存分类代码10 - Combustible liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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