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Anti- Smad2 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5701203
包装型号
规格纯度
参考价格
4668.88 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti- Smad2 antibody produced in rabbit
产品介绍:

产品说明

一般描述

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

免疫原

A synthesized peptide derived from human Smad2

外形

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

产品性质

生物来源rabbit
质量水平100
antibody product typeprimary antibodies
克隆monoclonal
形式liquid
species reactivitymouse, human, rat
浓度0.95 mg/mL
technique(s)immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000
UniProt登记号Q15796
运输wet ice
储存温度−20℃
Gene Informationhuman ... SMAD2(4087)

安全信息

闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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