产品说明
一般描述
The antibody detects endogenous levels of total ABL1/2 protein.
免疫原
Peptide sequence around aa. 391-395 (D-T-Y-T-A), according to the protein NP_005148.2, NP_001129472.1
特点和优势
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目标描述
Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 135-210 kDa |
| species reactivity | human, mouse |
| 浓度 | 1 mg/mL |
| technique(s) | western blot: 1:500-1:1000 |
| 同位素/亚型 | IgG |
| 免疫原序列 | (D-T-Y-T-A) |
| NCBI登记号 | NM_001136000.2 NM_005157.3 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... ABL1(25), ABL2(27) mouse ... ABL1(11350), ABL2(11352) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
