产品说明
一般描述
Angiotensin-converting enzyme-2 (ACE2), also referred as ACEH (human ACE homolog), is an integral membrane protein. It is encoded by the gene located at human chromosome Xp22.2. Ace 2 is found in variety of tissues, but the higher levels of protein is observed in vascular endothelium, lungs, heart, kidney, and testis. The protein contains a N-terminal single catalytic metallopeptidase unit, a C-terminal noncatalytic domain and a cytoplasmic tail.
免疫原
Antibody was raised against a synthetic peptide corresponding to amino acids near the C-terminus of human ACE2.
生化/生理作用
Angiotensin-converting enzyme-2 (ACE2) as a carboxypeptidase cleaves angiotensin (Ang) I to Ang 1-9. In addition, it also degrades Ang II to Ang 1–7 and plays a vital role in regulation of blood pressure. Ace 2 aids in maintaining the balance of local renin-angiotensin system (RAS). It also helps in absorbing the neutral amino acids from the intestine and the kidney. It is a cellular receptor for spike glycoprotein of severe acute respiratory syndrome-coronavirus (SARS-CoV) and the new coronavirus (SARS-CoV-2), which is known to cause coronavirus disease 2019 (COVID-19). Downregulated expression of Ace 2 has been observed in patients with cardiovascular diseases.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
联系
The action of this antibody can be blocked using blocking peptide SBP3500977.
外形
Supplied at 1 mg/mL in PBS with 0.02% sodim azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | predicted mol wt 89 kDa |
| species reactivity | human |
| 浓度 | 1 mg/mL |
| technique(s) | ELISA: suitable immunoblotting: suitable immunofluorescence: suitable immunohistochemistry: suitable |
| NCBI登记号 | NP_068576 |
| UniProt登记号 | Q9BYF1 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... ACE2(59272) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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