Anti-ACE2 antibody produced in rabbit

产品说明

一般描述

Angiotensin-converting enzyme-2 (ACE2) gene is mapped to human chromosome Xp22.2. The gene codes for a membrane-associated and secreted enzyme. Ace 2 is a human homolog of angiotensin-converting enzyme (ACE) and is found mainly on endothelium. In humans, Ace2 is exclusively expressed in heart, kidney, and testis. The protein is characterized with an N-terminal PD and a C-terminal collectrin-like domain (CLD).

免疫原

Antibody was raised against a synthetic peptide corresponding to amino acids near the N terminus of human ACE2.

生化/生理作用

Angiotensin-converting enzyme-2 (ACE2) aids in maturation of angiotensin (Ang) by converting Ang I to Ang1-9. It may also play a role in the local renin-angiotensin system (RAS) in heart and kidney. Ace 2 serves as a functional receptor for severe acute respiratory syndrome–coronavirus (SARS-CoV) and the new coronavirus (SARS-CoV-2), which is responsible for causing coronavirus disease 2019 (COVID-19). Reduced expression of Ace 2 might cause cardiovascular diseases.

特点和优势

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联系

The action of this antibody can be blocked using blocking peptide SBP3500978.

外形

Supplied at 1 mg/mL in PBS with 0.02% sodim azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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