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位置:首页 > 品牌 > Sigma-Aldrich > Anti-acetyl-Histone H3 (Lys9) Antibody, clone RM161

Anti-acetyl-Histone H3 (Lys9) Antibody, clone RM161

品牌
Sigma-Aldrich
货号
MABE645
规格纯度
clone RM161, from rabbit
参考价格
7029.8 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-acetyl-Histone H3 (Lys9) Antibody, clone RM161
Histone H3.3, Histone H3
产品介绍:

产品说明

一般描述

Histone H3, also known as Histone H3.1t (H3/t), H3t, H3/g, and encoded by the gene name HIST3H3/ H3FT, is a core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Therefore, histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. High levels of phosphorylation of Histone H3 are associated with mitosis.

特异性

This antibody reacts to Histone H3 acetylated at Lysine 9 (K9ac). No cross reactivity with other acetylated Lysines in Histone H3.

免疫原

A linear peptide corresponding to human Histone H3 acetylated at Lys9.

应用

This Anti-acetyl-Histone H3 (Lys9) Antibody, clone RM161 is validated for use in Western Blotting, Multiplexing for the detection of acetyl-Histone H3.

质量

Evaluated by Western Blotting in untreated and sodium butyrate treated HeLa acid extract.

Western Blotting Analysis (WB): 0.25 μg/mL of this antibody detected acetyl-Histone H3 (Lys9) in sodium butyrate treated HeLa acid extract.

目标描述

~17 kDa observed. Uncharacterized bands may be observed in some lysate(s).

外形

Protein A purified
Format: Purified

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式purified antibody
antibody product typeprimary antibodies
克隆RM161, monoclonal
species reactivityhuman
technique(s)multiplexing: suitable
western blot: suitable
同位素/亚型IgG
UniProt登记号P84243
运输wet ice
Gene Informationhuman ... H3F3B(3021)

Sigma-Aldrich

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