Anti-ADAP Antibody

产品说明

一般描述

The adhesion and degranulation adaptor protein (ADAP) acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. ADAP modulates the expression of interleukin-2 (IL-2) and it is suggested to be involved in platelet activation. Additionally ADAP is shown to prevent the degradation of SKAP1 and SKAP2 and may play a role in linking T-cell signaling to the remodeling of the actin cytoskeleton. ADAP is expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. At least two isoforms of ADAP are known to exist.

特异性

This antibody recognizes the C-terminus of ADAP.

免疫原

KLH-conjugated linear peptide corresponding to the C-terminus of human ADAP.
Epitope: C-terminus

应用

Research Category
Cell Structure
Detect ADAP using this rabbit polyclonal antibody, Anti-ADAP Antibody validated for use in western blotting & ICC.
Immunocytochemistry Analysis: 10 µg/mL from a representative lot detected ADAP in K562 cells.
Research Sub Category
Adhesion (CAMs)

质量

Evaluated by Western Blotting in K562 cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected ADAP in 15 µg of K562 cell lysate.

目标描述

~130 kDa observed. Uncharacterized bands may appear in some lysates. Uniprot describes 2 isoforms at ~85 kDa and ~91 kDa

外形

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
K562 cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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