产品说明
一般描述
Adipocyte differentiation-related protein is associated with the globule surface membrane material. This protein is a major constituent of the globule surface. Increase in mRNA levels is one of the earliest indications of adipocyte differentiation (provided by RefSeq)
Adipose differentiation-related protein (ADRP), also known as adipose differentiation-related protein (ADFP), is the major lipid droplet protein. It is encoded by the gene mapped to human chromosome 9p22.1–p21.3. ADFP is ubiquitously expressed and is a member of PAT (perilipin/APRP/TIP47) family.
免疫原
ADFP (NP_001113.2, 1 a.a. ~ 437 a.a) full-length human protein.
Sequence
MASVAVDPQPSVVTRVVNLPLVSSTYDLMSSAYLSTKDQYPYLKSVCEMAENGVKTITSVAMTSALPIIQKLEPQIAVANTYACKGLDRIEERLPILNQPSTQIVANAKGAVTGAKDAVTTTVTGAKDSVASTITGVMDKTKGAVTGSVEKTKSVVSGSINTVLGSRMMQLVSSGVENALTKSELLVEQYLPLTEEELEKEAKKVEGFDLVQKPSYYVRLGSLSTKLHSRAYQQALSRVKEAKQKSQQTISQLHSTVHLIEFARKNVYSANQKIQDAQDKLYLSWVEWKRSIGYDDTDESHCAEHIESRTLAIARNLTQQLQTTCHTLLSNIQGVPQNIQDQAKHMGVMAGDIYSVFRNAASFKEVSDSLLTSSKGQLQKMKESLDDVMDYLVNNTPLNWLVGPFYPQLTESQNAQDQGAEMDKSSQETQRSEHKTH
生化/生理作用
Adipose differentiation-related protein (ADFP) plays a vital role in lipid droplet (LD) formation and/or maturation. Increased expression of this protein in tamm-horsfall protein 1 (THP-1) macrophages increases lipid accumulation and stops lipid efflux. In addition, ADFP is slightly involved in maintenance of adipose tissue homeostasis. It acts as a potential marker for intracellular LD in tissues.
外形
Solution in phosphate buffered saline, pH 7.4
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~48.1 kDa |
| species reactivity | human |
| technique(s) | western blot: 1 μg/mL |
| NCBI登记号 | NM_001122.2 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... ADFP(123) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
