Anti-ADORA2A antibody produced in mouse

产品说明

一般描述

Adenosine A2A receptor (ADORA2A) or A2AR is a heptaspanning-membrane-receptor (HSMR) expressed majorly in the basal ganglia especially in the γ-aminobutyric acid (GABA)ergic striatopallidal neurons. The ADORA2A gene is mapped to human chromosome 22q11.23.

免疫原

ADORA2A (NP_000666, 1 a.a. ~ 412 a.a) full-length human protein.

Sequence
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS

生化/生理作用

Mutation in the adenosine A2A receptor (ADORA2A) gene is implicated in the pathophysiology of autism spectrum disorders (ASDs) and panic disorder. A2AR mediates the release of neurotransmitters in γ-aminobutyric acid (GABA)ergic neurons in rats.
ADORA2A activation leads to increased levels of cAMP within the cell. It is known to inhibit the inflammatory action of neutrophil. Abnormal expression of ADORA2A (adenosine A2a receptor) might be involved in the development of glioma. Also, downregulation of the gene might promote the susceptibility towards tumor-associated epilepsy.

外形

Solution in phosphate buffered saline, pH 7.4

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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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