产品说明
一般描述
This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.
免疫原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human ALIX / PDCD6IP (NP_037506.2).
外形
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
储存及稳定性
Store at -20℃. Avoid freeze / thaw cycles.
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 30 96 |
| species reactivity | human, mouse, rat |
| 浓度 | 3.76 mg/ml |
| technique(s) | immunofluorescence: 1:50-1:200 immunohistochemistry: 1:50-1:200 western blot: 1:200-1:2000 |
| UniProt登记号 | Q8WUM4 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... PDCD6IP(10015) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
