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Anti-Annexin 4 antibody,Mouse monoclonal

品牌
Sigma-Aldrich
货号
SAB4200121
规格纯度
clone ANX47, purified from hybridoma cell culture
参考价格
5045.46 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Annexin 4 antibody,Mouse monoclonal
Anti-Placental anticoagulant protein II
Anti-PIG28
Anti-Zymogen granule membrane-associated protein, 36-KD
Anti-ZAP36
Anti-ANXA4
Anti-ANX4
产品介绍:

产品说明

一般描述

Annexin A4 is encoded by the gene mapped to human chromosome 2p13.3. The encoded protein belongs to the Ca2+-regulated and phospholipid-binding annexin superfamily proteins. Annexin A4 is highly expressed in epithelial cells.
Monoclonal Anti-Annexin 4 (mouse IgG1 isotype) is derived from the hybridoma ANX47 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant human Annexin 4 protein.

免疫原

recombinant human Annexin 4 protein

应用

The product may be used in several immunochemical techniques including immunoblotting and immunohistochemistry.

生化/生理作用

Elevated expression of annexin A4 leads to development of various cancers such as colorectal cancer (CRC), esophageal squamous cell carcinoma (ESCC), endometrial carcinoma (EC), gastric cancer (GC), chemoresistant lung cancer (LC), malignant mesothelioma (MM), renal cell carcinoma (RCC), ovarian clear cell carcinoma (OCCC), cholangiocarcinoma, hepatocellular carcinoma (HCC), breast cancer (BC) and laryngeal cancer. Thus, annexin A4 can be used in diagnosis, prognosis and treatment of these cancers. In addition, the encoded protein acts as a tumor suppressor for prostate cancer (PCa) and has a contradictory role for pancreatic cancer (PCC).
The major involvement of Annexin 4 is seen in membrane permeability, exocytosis and regulation of ion channels. Its role in membrane fluidity and membrane trafficking may explain in part the involvement of Annexin 4 in modulating drug resistance in cancer cells. Indeed, Annexin 4 was found to confer chemoresistance in ovarian cancer cells in part by enhancing drug efflux.

外形

Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品性质

生物来源mouse
偶联物unconjugated
抗体形式purified from hybridoma cell culture
antibody product typeprimary antibodies
克隆ANX47, monoclonal
形式buffered aqueous solution
分子量antigen 34 kDa
species reactivitymouse, bovine, monkey, human
包装antibody small pack of 25 μL
浓度~1.5 mg/mL
technique(s)immunohistochemistry: suitable
western blot: 2-4 μg/mL using A431 total cell extracts
同位素/亚型IgG1
UniProt登记号P09525
运输dry ice
储存温度−20℃
Gene Informationhuman ... ANXA4(307)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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